Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects

By L. Ortiz, F. Gambelli, C. McBride, Dina Gaupp, M. Baddoo, Naftali Kaminski, D. Phinney. Proceedings of the National Academy of Sciences of the United States of America, 2003

1,465 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Surgery

View Paper: https://www.semanticscholar.org/paper/9d248edc903e472250b2d5c5fac74f17cf6560f8

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In Genetics

1. Michael A. Matthay
2. Rocky S. Tuan
3. Frank Barry
4. C. Gregory
5. L. Song
6. Jeffrey L Spees
7. D. Baksh
8. R. Lee

In Surgery

1. Rocky S. Tuan
2. C. Gregory
3. Michael A. Matthay
4. Jeffrey L Spees
5. R. Lee
6. Elizabeth Cho
7. Catherine M. Kolf

Citations in the corpus

• Mesenchymal stem cells: clinical applications and biological characterization. (2004, methodology): “These observations lead to the development of elegant methods involving CD34/CD45/CD11b immunodepletion to generate purified MSC preparations (Ortiz et al., 2003).”
• Bone marrow-derived mesenchymal stem cells in repair of the injured lung. (2005, background): “In the lung, BMDMSC have been detected as type I and type II alveolar epithelial cells, endothelial cells, fibroblasts, and bronchial epithelial cells (5).”
• Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy (2004, background): “They not only regenerate tissues of mesenchymal lineages, such as intervertebral disc cartilage [72], bone [73, 74], cardiomyocytes [75], and articular cartilage at knee joints [76], but also differentiate into cells derived from other embryonic layers, including neurons [77] and epithelia in skin, ”
• Mechanisms of mesenchymal stem/stromal cell function (2016, background): “demonstrated that systemic murine MSC administration attenuated fibrosis in a bleomycin-induced lung injury model [108].”
• Epithelial repair mechanisms in the lung. (2010, background): “Ortiz and collaborators (114) used an enriched population of BMSC that were depleted of hematopoietic cell types, and demonstrated lung engraftment following bleomycin injury, the presence of donor-derived cells among isolated ATII cells, and reduced bleomycin-induced injury.”
• Intrapulmonary Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Survival and Attenuates Endotoxin-Induced Acute Lung Injury in Mice1 (2007, methodology): “(3) used bone marrow cells that were immunodepleted for cells expressing CD45, CD11b, and CD34 to isolate a purified population of MSC.”