Continuous Particle Separation Through Deterministic Lateral Displacement

By L. R. Huang, E. Cox, R. Austin, J. Sturm. Science, 2004

1,499 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/9cf3bef66e9d1baa085e7d1262ea09777b5823cd

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In Biomedical Engineering

Citations in the corpus

Blood-on-a-chip. (2005, background): “In one example, particles are separated through differential lateral displacement owing to asymmetric bifurcation of laminar flow around obstacles with sizes comparable to the size of the particles (Figure 2) (15).”
Microfluidics for cell separation (2010, methodology): “The micro-pillars are suitably placed in the microchannel such that cells larger than the critical diameter dc = 20% 9 2w (w is the separation gap between two adjacent pillars) follow a deterministic path while smaller cells maintain an average downward flow direction around the pillars, leading to ”
A review of microfabrication techniques and dielectrophoretic microdevices for particle manipulation and separation (2014, background): “(3) The hydrodynamic technique presumes that particles will follow the fluid streamlines at a low Reynolds number, which has been applied within microchannels having multiple side branch channels [43], a pinched segment [44], or micro-obstacle arrays [45], and the separation of different-sized polys”
Continuous Inertial Focusing and Separation of Particles by Shape (2012, background): “[25]; and inertial separation in curved channels or spirals”
Particle inertial focusing and its mechanism in a serpentine microchannel (2014, methodology): “Active techniques such as dielectrophoresis (DEP) (Çetin and Li 2011), magnetophoresis 30 (MP) (Forbes and Forry 2012) and acoustophoresis (AP) (Wang and Zhe 2011) rely on an external force field, whereas passive techniques depend entirely on the channel geometry or intrinsic hydrodynamic forces, su”
Label-free cell separation and sorting in microfluidic systems (2010, methodology): “It has a very good size resolution, capable of resolving a 10-nm size difference [46] and has been demonstrated to be effective for cell size measurement [50].”
Efficient microfluidic particle separation arrays (2009, background): “Passive separation of microparticles by size can be accomplished in two-dimensional arrays of posts called deterministic lateral displacement (DLD) arrays [1, 2].”
Advanced Materials and Processing for Drug Delivery: The Past and the Future (2012, neutral): “In fact, continuous particle sorting based on size has been carried out in microfluidics using optical lattice [188], sedimentation [189], hydrodynamic filtration [190], and lateral displacement [191].”
Inertial Focusing for Tumor Antigen–Dependent and –Independent Sorting of Rare Circulating Tumor Cells (2013, methodology): “After labeling, the first stage within the CTCiChip used hydrodynamic size–based sorting to achieve low shear microfluidic debulking of whole blood (22, 24).”