Hyaluronic acid: A key molecule in skin aging
By E. Papakonstantinou, M. Roth, G. Karakiulakis. Dermato-Endocrinology, 2012
926 citations recorded by the source corpus.
Skin aging is a multifactorial process consisting of two distinct and independent mechanisms: intrinsic and extrinsic aging. Youthful skin retains its turgor, resilience and pliability, among others, due to its high content of water. Daily external injury, in addition to the normal process of aging, causes loss of moisture. The key molecule involved in skin moisture is hyaluronic acid (HA) that has unique capacity in retaining water. There are multiple sites for the control of HA synthesis, deposition, cell and protein association and degradation, reflecting the complexity of HA metabolism. The enzymes that synthesize or catabolize HA and HA receptors responsible for many of the functions of HA are all multigene families with distinct patterns of tissue expression. Understanding the metabolism of HA in the different layers of the skin and the interactions of HA with other skin components will facilitate the ability to modulate skin moisture in a rational manner.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/9cc462f696ec067e29bbe3a3ed52d03960390fd7
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In Molecular Biology
Citations in the corpus
- The Roles of Vitamin C in Skin Health (2017, background): “Dry skin is very common in older adults [127], largely due to a loss of glycosaminoglycans and accompanied reduction in the ability to maintain moisture levels [126,128].”