Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

By D. Ge, J. Fellay, A. Thompson, J. Simon, K. Shianna, T. Urban, E. Heinzen, P. Qiu, A. Bertelsen, A. Muir and 3 more. Nature, 2009

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An Update on Treatment of Genotype 1 Chronic Hepatitis C Virus Infection: 2011 Practice Guideline by the American Association for the Study of Liver Diseases (2011, background): “One single-nucleotide polymorphism that is highly predictive is detection of the C or T allele at position rs12979860.(19) The CC genotype is found more than twice as frequently in persons who have spontaneously cleared HCV infection than in those who had progressed to CHC.”
Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the international encephalitis consortium. (2013, background): “In infectious disease, testing for HLA-B5701 is used to identify patients infected with human im-munode ﬁ ciency virus (HIV) at risk for abacavir hypersensitivity [62], and IL-28B genotype may predict the clinical ef ﬁ cacy of interferon regimens for hepatitis C [63].”
Into the Eye of the Cytokine Storm (2012, background): “Several GWAS have also identified variants of IFN- 3 that were associated with spontaneous resolution and successful treatment of hepatitis C virus (HCV) infection (55, 140).”