Inflammation: the link between insulin resistance, obesity and diabetes.

By P. Dandona, A. Aljada, A. Bandyopadhyay. Trends in immunology, 2004

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Increased Hepatic and Circulating Interleukin-6 Levels in Human Nonalcoholic Steatohepatitis (2008, background): “Since obesity, diabetes, and even impaired glucose tolerance are associated with increased levels of circulating IL-6”
Mechanisms of obesity-associated insulin resistance: many choices on the menu. (2007, background): “Thus, a better understanding of the molecular mechanisms underlying insulin resistance will be required to combat the epidemics of T2DM and cardiovascular disease that are fueled by obesity-associated insulin resistance.”
Glycogen Synthase Kinase-3 (GSK3): Inflammation, Diseases, and Therapeutics (2007, neutral): “signaling [145, 146].”
Brain-derived neurotrophic factor (BDNF) and type 2 diabetes (2007, background): “Inflammation has been suggested as a key factor in insulin resistance [30].”
Inflammation and metabolic disorders (2006, background): “Unequivocal experimental, epidemiological and clinical evidence produced during the past decade causally links inflammation, or the molecules and networks integral to inflammatory responses, to the development of these metabolic diseases and/or the complications that emerge from these pathologies, p”
Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation. (2005, background): “Low-grade systemic inflammation is a feature of obesity and insulin resistance (1).”