Metabolic Effects of Intermittent Fasting

By Ruth Patterson, Dorothy D. Sears. Annual review of nutrition, 2017

700 citations recorded by the source corpus.

The objective of this review is to provide an overview of intermittent fasting regimens, summarize the evidence on the health benefits of intermittent fasting, and discuss physiological mechanisms by which intermittent fasting might lead to improved health outcomes. A MEDLINE search was performed using PubMed and the terms “intermittent fasting,” “fasting,” “time-restricted feeding,” and “food timing.” Modified fasting regimens appear to promote weight loss and may improve metabolic health. Several lines of evidence also support the hypothesis that eating patterns that reduce or eliminate nighttime eating and prolong nightly fasting intervals may result in sustained improvements in human health. Intermittent fasting regimens are hypothesized to influence metabolic regulation via effects on (a) circadian biology, (b) the gut microbiome, and (c) modifiable lifestyle behaviors, such as sleep. If proven to be efficacious, these eating regimens offer promising nonpharmacological approaches to improving health at the population level, with multiple public health benefits.

Subfields: Endocrine and Autonomic Systems, Physiology

View Paper: https://www.semanticscholar.org/paper/9b50b85e1e69a06d9c649c85736390c4cee8c288

How researchers see this paper

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In Endocrine and Autonomic Systems

1. E. Ravussin

In Physiology

1. C. Peterson
2. E. Ravussin
3. K. Early
4. W. Cefalu
5. R. Beyl
6. Elizabeth F Sutton

Citations in the corpus

• Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes. (2018, positive): “Intermittent fasting (IF)—the practice of alternating periods of eating and fasting—has emerged as an effective therapeutic strategy for improving multiple cardiometabolic endpoints in rodent models of disease, ranging from insulin sensitivity and ectopic fat accumulation to hard endpoints such as s”