Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR
By J. Ardenkjær-Larsen, B. Fridlund, Andreas Gram, G. Hansson, L. Hansson, M. Lerche, R. Servin, M. Thaning, K. Golman. Proceedings of the National Academy of Sciences of the United States of America, 2003
2,665 citations recorded by the source corpus.
Subfields: Atomic and Molecular Physics, and Optics, Nuclear and High Energy Physics, Spectroscopy
View Paper: https://www.semanticscholar.org/paper/9b2954e8e5126b5f48ff0f4bf54e5559062ac52a
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Citations in the corpus
- Detecting treatment response in a model of human breast adenocarcinoma using hyperpolarised [1-13C]pyruvate and [1,4-13C2]fumarate (2010, background): “This situation may change with the recent introduction of a dynamic nuclear polarisation (DNP) technique that can increase sensitivity in the solution state 13C MRS experiment by 410 000-fold (Ardenkjaer-Larsen et al, 2003).”
- Ultrafast two-dimensional nuclear magnetic resonance spectroscopy of hyperpolarized solutions (2007, background): “A number of hyperpolarization techniques have been explored to boost NMR’s sensitivity, including an ex situ dynamic nuclear polarization method capable of yielding—for an array of molecules and under conventional observation conditions for liquid samples—signals that exceed those currently afford”
- Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research. (2011, methodology): “Many studies have made use of smalltip angle pulse sequences [80,105,108–112].”
- Glutaminolysis: A Hallmark of Cancer Metabolism. (2017, methodology): “In this technique, the 13C-labeled tracer is “hyperpolarized” through exposure to microwaves at extremely low temperatures, in a technique termed dynamic nuclear polarization (DNP), immediately prior to tracer administration and scanning (164).”
- Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy (2006, methodology): “The mixture is thawed before imaging, and polarization is retained even after the probe has been thawed and injected into the animal (Ardenkjaer-Larsen et al. 2003).”
- The Future of NMR-Based Metabolomics (2016, background): “First demonstrated by Golman and coworkers [51], studies utilizing hyperpolarized (13)C to increase sensitivity are becoming routine.”