The Future of NMR-Based Metabolomics
By John L. Markley, R. Brüschweiler, A. Edison, Hamid R. Eghbalnia, Robert Powers, D. Raftery, David S. Wishart. Current Opinion in Biotechnology, 2016
769 citations recorded by the source corpus.
The two leading analytical approaches to metabolomics are mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy. Although currently overshadowed by MS in terms of numbers of compounds resolved, NMR spectroscopy offers advantages both on its own and coupled with MS. NMR data are highly reproducible and quantitative over a wide dynamic range and are unmatched for determining structures of unknowns. NMR is adept at tracing metabolic pathways and fluxes using isotope labels. Moreover, NMR is non-destructive and can be utilized in vivo. NMR results have a proven track record of translating in vitro findings to in vivo clinical applications.
Subfields: Molecular Biology, Radiology, Nuclear Medicine and Imaging, Spectroscopy
View Paper: https://www.semanticscholar.org/paper/4aa6d261a9bc9cbcf7bb8019f2156c23bda4ffd0
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Citations in the corpus
- Metabolomics and isotope tracing (2018, background): “This is feasible due to advances in metabolite measurement technologies like NMR and mass spectrometry (MS) (Fiehn, 2002; Beckonert et al., 2007).”