Diverse taxa of cyanobacteria produce beta-N-methylamino-L-alanine, a neurotoxic amino acid.

By P. Cox, S. Banack, S. Murch, U. Rasmussen, G. Tien, R. Bidigare, J. Metcalf, L. F. Morrison, G. Codd, B. Bergman. Proceedings of the National Academy of Sciences of the United States of America, 2005

697 citations recorded by the source corpus.

Subfields: Ecology, Ecology, Evolution, Behavior and Systematics, Environmental Chemistry

View Paper: https://www.semanticscholar.org/paper/9ad84f810f62bf74c5adfd69b0f97ee106b5ec3b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Ecology

In Ecology, Evolution, Behavior and Systematics

In Environmental Chemistry

Citations in the corpus

Emerging threats and persistent conservation challenges for freshwater biodiversity (2018, background): “BMAA biosynthesis is thought to be a ubiquitous trait shared among most genera of cyanobacteria (Cox et al. , 2005) and can accumulate in aquatic food webs plagued by cyanoHABs (Brand et al. , 2010; Jiao et al. , 2014).”
Harmful Cyanobacterial Blooms: Causes, Consequences, and Controls (2013, background): “), the more cumbersome their management will become [22, 31, 62].”
Crayfish invading Europe: the case study of Procambarus clarkii (2006, background): “Crayfish are able to accumulate in their tissues the toxins and possibly BMAA ( -N-methylamino-L-alanine) produced by cyanobacteria and to transfer them to their predators, humans included, inducing lethal intoxications (e.g. Carmichael 1988; Cox et al. 2005).”
Bioactive lichen metabolites: alpine habitats as an untapped source (2011, background): “Microcystins, hepatotoxic cyclic heptapeptides were produced by a Nostoc sp. isolated from the lichen Pannaria pezizoides (Oksanen et al. 2004), and b-N-methylamino-L-alanine, a neurotoxic amino acid is produced by a Nostoc sp. from a Peltigera sp. (Cox et al. 2005).”
Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly. (2017, background): “Toxic forms of neurodegenerative diseases have been described, such as ALS-dementia of Guam (Cox et al., 2003) due to N-β -methylamino-L-alanine (BMAA) produced by Cyanobacteria (Cox et al., 2005).”
Cyanobacteria and cyanotoxins in Polish freshwater bodies (2013, background): “The group of cyanobacterial neurotoxins includes the nonproteogenic amino acid β-N-methylamino-Lalanine (BMAA) (Cox et al. 2005, Jonasson et al. 2010), alkaloid compounds such as anatoxin-a, homoanatoxin-a, anatoxin-a(s) and saxitoxins (Aráoz et al. 2010).”
Harmful Algal Blooms (2015, background): “More recently, the nonprotein amino acid BMAA was identified as a neurotoxin and considered to be widely produced among cyanobacteria (Cox et al., 2005).”
Sustainability and cyanobacteria (blue-green algae): facts and challenges (2011, background): “…nerve cells Wu et al. 2000 β-N-methylaminoL alanine Microcystis, Anabaena, Nostoc and Planktothrix spp. Lateral sclerosis/parkinsonism-dementia complex Cox et al. 2005 Spiroidesin Anabena spiroides Inhibits cell growth Kaya et al. 2002 which might be used in manufacturing biodegradable…”
Review and analysis of occurrence, exposure and toxicity of cyanobacteria toxins in food (2016, background): “In addition, it has been found that A. flos-aquae species can produce neurotoxins (Cox et al., 2005).”
Understanding the impact of invasive crayfish (2007, background): “Several Cyanobacteria release a wide range of toxins and BMAA (b-N-methylamino-l-alanine) that may produce lethal animal and human intoxications (e.g. Carmichael 1988, Cox et al. 2005).”
State of knowledge and concerns on cyanobacterial blooms and cyanotoxins. (2013, background): “BMAA has not been extensively studied yet but a recent work indicates that this toxin may be produced by all known groups of cyanobacteria (Cox et al., 2005).”