Subregional analysis of mnemonic functions of the prefrontal cortex in the rat

By R. Kesner. Psychobiology, 2000

135 citations recorded by the source corpus.

Evidence is reviewed to support the idea that in the rat prefrontal cortex there are differential sub-regional functional contributions to cognitive and memory function. It is proposed that the prefrontal cortex in the rat can be fractionated in terms of functions associated with a slightly revised rule model that incorporates a domain-specific and a level-of-processing model. It is proposed that there is a hierarchy of lower order, higher order, and highest order rules that can support different subregions of the rat prefrontal cortex. The lower order rules encompass rules associated with reversal learning. The higher order rules encompass rules associated with the different domains or attributes of working memory and cross-modal set switching. The highest order rules encompass rules associated with temporal order memory and paired associate learning and performance. It appears that there is a correspondence between rats and monkeys and between rats and humans in terms of prefrontal cortex function.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/9ab46e9b851fea3aa4b0409d2bc787062704ce04

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates. (2004, background): “Rats with lesions of the PrL and IL, but not ACg or orbitofrontal cortex, are profoundly impaired on such tasks when delays are imposed [34,72,76].”
The Prefrontal Cortex as a Key Target of the Maladaptive Response to Stress (2007, methodology): “Research on the detrimental effects of stress in the brain has mainly focused on the hippocampus.”