Interplay between the cancer genome and epigenome.

By Hui Shen, Peter W. Laird. Cell, 2013

842 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9ab23b6b3c6dd9d12ba9c5990f6273c42790ba59

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. E. Batlle
2. Wanding Zhou
3. Hui Shen
4. Timothy Triche
5. Peter W. Laird
6. J. Massagué
7. Thordur Oskarsson
8. P. Park

Citations in the corpus

• SeSAMe: reducing artifactual detection of DNA methylation by Infinium BeadChips in genomic deletions (2018, background): “The interplay between the epigenome and genome in human diseases such as cancer (52) has garnered much attention in recent years, in the hope of finding novel pathways and therapeutic targets.”
• Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials (2019, background): “Some of the alterations determine cell function and are involved in oncogenic transformation.(4) However, by reversing these mutations by drugs or gene therapy, the phenotype of cancer can revert to normal.”
• Metastatic Stem Cells: Sources, Niches, and Vital Pathways (2014, background): “Because this literature is not the primary focus of this review, we will refer readers to recent reviews for further reading on these topics (Shen and Laird, 2013; Ward and Thompson, 2012).”
• Epigenetic plasticity and the hallmarks of cancer (2017, background): “A major, unanticipated outcome of large-scale cancer genome sequencing projects is the finding that roughly 50% of human cancers harbor mutations in chromatin proteins (7, 8).”
• DNA Methylation in Cancer and Aging. (2016, background): “Using high-throughput technology to detect mutations in cancer, it has been demonstrated that many of the affected genes are involved in DNAmethylationmetabolism or in the control of chromatin structure (1), raising the possibility that the epigenetic state of tumors may just reflect one consequence”
• The somatic genomic landscape of chromophobe renal cell carcinoma (2014, background): “cancer-relevant pathways but may also reflect the cell of origin of the cancer (Shen and Laird, 2013).”
• Comprehensive characterization, annotation and innovative use of Infinium DNA methylation BeadChip probes (2016, background): “It has become increasingly clear that DNA methylation plays an important role in cancer (1), aging (2) and many other physiological or pathological conditions.”