Adult brain neurogenesis and psychiatry: a novel theory of depression

By B. Jacobs, H. van Praag, Fred H. Gage. Molecular Psychiatry, 2000

1,001 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Developmental Neuroscience, Social Psychology

View Paper: https://www.semanticscholar.org/paper/9aab4d19c51abb0f5b1197e66a7d9055388fe8a3

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Citations in the corpus

Structural neuroimaging studies in major depressive disorder. Meta-analysis and comparison with bipolar disorder. (2011, result): “The finding that hippocampal volume was significantly smaller in patients with a depressed compared with remitted state raises the possibility that reductions in hippocampal volume may normalize during remission, and it is tempting to speculate that this may be the result of neurogenesis in the dent”
The Darwinian concept of stress: benefits of allostasis and costs of allostatic load and the trade-offs in health and disease. (2005, background): “It was also recently hypothesized that therapeutic interventions for depression that increase 5-HT neurotransmission act, at least in part, by augmenting DG neurogenesis and thereby promoting recovery from depression [380].”
Mindfulness practice leads to increases in regional brain gray matter density (2010, background): “However, the hippocampus is a region well known for its ability to remodel synapses and generate new neurons (Gage, 2002), and volume loss in this region seems to be reversible (Gould et al., 2000; Jacobs et al., 2000).”
New design strategies for antidepressant drugs (2013, background): “An intriguing linkage between therapeutic antidepressant activity and hippocampal neurogenesis has been established over the last decade [61-65].”
The current state of the neurogenic theory of depression and anxiety. (2015, background): “First formally proposed in 2000, the neurogenic theory of depression posits that impaired adult hippocampal neurogenesis (AHN) triggers depression and restoration of AHN leads to recovery [2].”
Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice (2003, background): “In addition, there is support for adult hippocampal neurogenic dysfunction in major depression or dementia (Duman et al., 2000; Jacobs et al., 2000; Kempermann, 2002a).”
Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells (2006, background): “Jacobs et al. and later others suggested that insufficient hippocampal neurogenesis causally underlies depression (Jacobs et al. 2000; D’Sa & Duman 2002).”
Depression: An Evolutionarily Conserved Mechanism to Terminate Separation Distress? A Review of Aminergic, Peptidergic, and Neural Network Perspectives (2009, background): “Sustained elevation of cortisol is currently suspected to be the primary etiological factor for the modest reductions in hippocampal volume seen in patients with depression and posttraumatic stress disorder (PTSD) (Dranovsky & Hen, 2006; Jacobs et al., 2000), although this correlation still remains ”