Faculty Opinions recommendation of Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans.

By Matt Kaeberlein. 2011

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Subfields: Aging

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piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans (2012, background): “RNAi effects are generally systemic (soma and germline) and are observed in the F1 generation, but the latter requires the generation of secondary siRNAs (Grishok et al., 2000; Pak and Fire, 2007; Sijen et al., 2007; Gu et al., 2009).”
Epigenetics and aging (2016, background): “Instead, microarray analysis revealed that there were persistent changes in gene expression throughout the generations upon manipulation of the H3 K4me3 regulatory complex in the parents (198), which could potentially be responsible for the transgenerational inheritance of long life span.”
The hallmarks of aging. (2013, background): “Moreover, the recent discovery of transgenerational epigenetic inheritance of longevity in C. elegans suggests that manipulation of specific chromatin modifications in parents can induce an epigenetic memory of longevity in their descendants (Greer et al., 2011).”