Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Treatment-Resistant Depression
By D. Malone, D. Dougherty, A. Rezai, L. Carpenter, G. Friehs, E. Eskandar, Scott L. Rauch, S. Rasmussen, A. Machado, C. Kubu and 8 more. Biological Psychiatry, 2008
832 citations recorded by the source corpus.
Background We investigated the use of deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) for treatment refractory depression. Methods Fifteen patients with chronic, severe, highly refractory depression received open-label DBS at three collaborating clinical sites. Electrodes were implanted bilaterally in the VC/VS region. Stimulation was titrated to therapeutic benefit and the absence of adverse effects. All patients received continuous stimulation and were followed for a minimum of 6 months to longer than 4 years. Outcome measures included the Hamilton Depression Rating Scale—24 item (HDRS), the Montgomery-Asberg Depression Rating Scale (MADRS), and the Global Assessment of Function Scale (GAF). Results Significant improvements in depressive symptoms were observed during DBS treatment. Mean HDRS scores declined from 33.1 at baseline to 17.5 at 6 months and 14.3 at last follow-up. Similar improvements were seen with the MADRS (34.8, 17.9, and 15.7, respectively) and the GAF (43.4, 55.5, and 61.8, respectively). Responder rates with the HDRS were 40% at 6 months and 53.3% at last follow-up (MADRS: 46.7% and 53.3%, respectively). Remission rates were 20% at 6 months and 40% at last follow-up with the HDRS (MADRS: 26.6% and 33.3%, respectively). The DBS was well-tolerated in this group. Conclusions Deep brain stimulation of the VC/VS offers promise for the treatment of refractory major depression.
Subfields: Neurology
View Paper: https://www.semanticscholar.org/paper/99f0ace7b5f1a2b8f9e2394cd018c33eb7ef5fa0
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Citations in the corpus
- Reduced Caudate and Nucleus Accumbens Response to Rewards in Unmedicated Subjects with Major Depressive Disorder (2009, background): “Given mounting interest in the role of the accumbens in the pathophysiology of major depression, as exemplified by recent deep brain stimulation studies targeting this region (35, 36), our finding of reduced rewardrelated accumbal responses is nevertheless intriguing.”
- Mental Activity as the Bridge between Neural Biomarkers and Symptoms of Psychiatric Illness (2022, methodology): “For example, in our recent experiment, participants with MDD performed a reward-based decision-making task designed to probe two mental activities, goal-directed behavior and reward-evaluation, known to be altered in MDD. 1,13 We found a negative relationship between symptoms of anhedonia and goal-d”