Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells.

By W. Ng, Phillip J. Duggan, F. Ponchel, G. Matarese, G. Lombardi, A. Edwards, J. Isaacs, R. Lechler. Blood, 2001

667 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/99cfe868e9e6e8bd2d4c81a88074e082c2aaecb0

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In Immunology

1. Shimon Sakaguchi
2. K. Wing
3. A. Krieg
4. Yong‐jun Liu
5. M. Miyara
6. Tomoyuki Yamaguchi
7. T. Nomura
8. M. Ono

Citations in the corpus

• Infectious Tolerance (2002, background): “In contrast, in vitro studies clearly revealed that murine and human CD25 Treg cells inhibit T cell proliferation via cell contact and independent from soluble factors (6, 8).”
• Human Plasmacytoid Dendritic Cells Activated by CpG Oligodeoxynucleotides Induce the Generation of CD4+CD25+ Regulatory T Cells1 (2004, background): “There is a possibility that although CpG ODN-treated PDCs up-regulate costimulatory molecules, there may be a concomitant up-regulation of suppressive surface molecules such as Ig-like transcripts 3 and 4 (51, 52) and Notch receptor ligands (50, 53, 54) as well as down-regulation of surface markers ”
• Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases. (2004, background): “…cells, CD4+CD25+ Treg cells play a role in the induction of tolerance (Sakaguchi et al., 1995; Taylor et al., 2001; Beacher-Allan et al., 2001; Jonuleit et al., 2001; Levings et al., 2001; Ng et al., 2001; Stephens et al., 2001; Cohen et al., 2002; Hoffmann et al., 2002; Word and Sakaguchi, 2003).”
• Increase of regulatory T cells in the peripheral blood of cancer patients. (2003, result): “Moreover, in contrast to CD4 CD25 T cells, propagated CD4 CD25 T cells expressed cell surface TGF- and CTLA-4, which is in line with recent reports demonstrating the expression of these two molecules on Tregs (8, 19).”
• Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. (2009, background): “Human natural Treg cells were initially defined according to their high expression of CD25 (Baecher-Allan et al., 2001; Dieckmann et al., 2001; Jonuleit et al., 2001; Levings et al., 2001; Ng et al., 2001; Taams et al., 2001), based on the finding that murine CD25CD4 T cells are highly suppressive (”