Calcium Phosphate Nanocomposite Particles for In Vitro Imaging and Encapsulated Chemotherapeutic Drug Delivery to Cancer Cells

By M. Kester, Yasser Heakal, Todd E Fox, Arati Sharma, Gavin P. Robertson, Thomas T. Morgan, Erhan Altinoglu, A. Tabaković, Mylisa R Parette, Sarah M Rouse and 2 more. Nano letters (Print), 2008

862 citations recorded by the source corpus.

Paradigm-shifting modalities to more efficiently deliver drugs to cancerous lesions require the following attributes: nanoscale-size, targetability and stability under physiological conditions. Often, these nanoscale drug delivery vehicles are limited due to agglomeration, poor solubility or cytotoxicity. Thus, we have designed a methodology to encapsulate hydrophobic antineoplastic chemotherapeutics within a 20-30 nm diameter, pH-responsive, non-agglomerating, non-toxic calcium phosphate nanoparticle matrix. In the present study, we report on calcium phosphate nanocomposite particles (CPNP) that encapsulate both fluorophores and chemotherapeutics, are colloidally stable in physiological solution for extended time at 37°C and can efficaciously deliver hydrophobic antineoplastic agents, such as ceramide, in several cell model systems.

Subfields: Biomaterials, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/99cd8f2d03fd1203f20a06acfad7331f3168fae2

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In Biomaterials

B. Kandasubramanian

In Molecular Biology

Citations in the corpus

pH-sensitive nano-systems for drug delivery in cancer therapy. (2014, positive): “CaP nanoparticles provide a pH-tunable method to deliver encapsulated molecules to targeted cells with minimal background release (Kester et al., 2008; Rim et al., 2011).”
Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review (2011, neutral): “Thus, non-immunogenic response, non-toxic degradation products, and pHdependent solubility make CaPs also suitable for intracellular imaging and drug delivery applications [75,76] in the form of NPs in addition to being a bone substituent.”
Nanoparticles for Biomedical Imaging: Fundamentals of Clinical Translation (2010, positive): “NP formation can also be controlled using ion and surfactant concentrations, pH, ionic strength, and temperature.(101,102) Because of their composition, calcium phosphate NPs have a lower likelihood of toxicity compared to other types of NPs.”
Functionalized graphene materials for hydrogen storage (2020, background): “[70] Boukhvalov DW, Katsnelson MI (2008) Chemical func-”
Spectroscopic investigation of defects in two-dimensional materials (2016, background): “If the location of defects can be controlled, novel graphene-based materials can be prepared for application in spintronic devices, catalyst, PN junction and so on [25-27].”
Structural defects in graphene. (2011, background): “Stone-Wales defects in nanoribbons may already create new states in the gap.(66) The position of the”