The POT1–TPP1 telomere complex is a telomerase processivity factor
By Feng Wang, E. Podell, A. Zaug, Yuting Yang, Paul Baciu, T. Cech, M. Lei. Nature, 2007
733 citations recorded by the source corpus.
Subfields: Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/9999c7ce34b58cd3991526455de54f116ad36fab
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- J. Karlseder
- de Lange
- Wilhelm Palm
- D. Hockemeyer
- T. de Lange
- Roderick J. O’Sullivan
- Peter M. Lansdorp
- G. Aubert
In Physiology
- J. Karlseder
- de Lange
- T. de Lange
- Wilhelm Palm
- D. Hockemeyer
- Roderick J. O’Sullivan
- Peter M. Lansdorp
- G. Aubert
Citations in the corpus
- Telomeres and aging. (2008, background): “” The TPP1/POT1 recruits and stimulates enzymatic activity of telomerase (222) preferentially at short telomeres (205).”
- Advance Publication by J-STAGE Japanese Journal of Infectious Diseases Isolation of human coronaviruses OC43, HKU1, NL63, and 229E in Yamagata, Japan, using primary human airway epithelium cells cultured by employing an air-liquid interface culture (2020, unknown): “Notably, although TPP1 does not directly bind to telomeric DNA, it increases the binding affinity of POT1 to telomeric DNA by 5–10 fold [35].”
- How shelterin solves the telomere end-protection problem. (2010, background): “POT1 is recruited to telomeres through its interaction with TPP1, another OB-foldcontaining protein (Liu et al. 2004; Ye et al. 2004b; Hockemeyer et al. 2007; Wang et al. 2007; Palm et al. 2009; Kibe et al. 2010).”
- How shelterin protects mammalian telomeres. (2008, background): “Furthermore, recent structural analysis has revealed the presence of an OB fold in TPP1 with considerable similarity to the OB fold of the TEBPβ subunit (193).”
- Telomere protection by mammalian Pot1 requires interaction with Tpp1 (2007, background): “Recently, crystallography has shown that the telomeric protein Tpp1 carries an OB fold with structural similarity to TEBPβ, and biochemical evidence has indicated that, like TEBPα and TEBPβ, Pot1 and Tpp1 bind DNA cooperatively in vitro”
- Telomeres: protecting chromosomes against genome instability (2010, background): “A direct interaction between TPP1 and telomerase has been shown to bolster telomerase processivit”