Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes.

By B. Altenberg, K. Greulich. Genomics, 2004

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Pyruvate Kinase M2 regulates Hif-1α activity and IL-1β induction, and is a critical determinant of the Warburg Effect in LPS-activated macrophages (2015, positive): “PKM2 on the other hand is upregulated in tumors (Altenberg and Greulich, 2004) and exists primarily as an enzymatically inactive monomer or dimer.”
Causes and Consequences of Increased Glucose Metabolism of Cancers (2008, background): “Genes of glycolysis are ubiquitously overexpressed in cancers (64) (65).”
PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis (2012, positive): “This line of evidence establishes PKM2 as a unique and key regulator of cancer development by virtue of its coordination of ATP generation, macromolecular syntheses, and gene transcription via both metabolic and nonmetabolic functions.”
Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth (2011, positive): “40) (Altenberg and Greulich, 2004; Majumder et al., 2004), which catalyzes the transfer of phosphate from phosphoenolpyruvate (PEP) to ADP, resulting in the formation of pyruvate and ATP.”