Nanoparticles that Communicate In Vivo to Amplify Tumour Targeting
By G. von Maltzahn, Ji-Ho Park, Kevin Y. Lin, Neetu Singh, C. Schwöppe, R. Mesters, W. Berdel, Erkki Ruoslahti, Michael J. Sailor, Sangeeta N. Bhatia. Nature Materials, 2011
487 citations recorded by the source corpus.
Nanomedicines have enormous potential to improve the precision of cancer therapy, yet our ability to efficiently home these materials to regions of disease in vivo remains very limited. Inspired by the ability for communication to improve targeting in biological systems, such inflammatory cell recruitment to sites of disease, we construct systems where synthetic biological and nanotechnological components communicate to amplify disease targeting in vivo. These systems are composed of ‘Signalling’ modules (nanoparticles or engineered proteins) that target tumours and then locally active the coagulation cascade to broadcast tumour location to clot-targeted ‘Receiving’ nanoparticles in circulation that carry a diagnostic or therapeutic cargo, thereby amplifying their delivery. We show that communicating nanoparticle systems can be composed from multiple types of Signalling and Receiving modules, can transmit information via multiple molecular pathways in coagulation, can operate autonomously, and can target over 40-fold higher doses of chemotherapeutics to tumours than non-communicating controls.
Subfields: Electronic, Optical and Magnetic Materials, Materials Chemistry, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/9850c0bc87dd6b36d75a5118d73bfae7d15d8af3
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
Citations in the corpus
- Mesoporous silica nanoparticles in medicine--recent advances. (2013, background): “Recently even more complex targeting utilizing nanoparticle induced biological communication pathways to amplify tumor targeting was shown to be a successful approach [81].”
- Treating metastatic cancer with nanotechnology (2011, background): “Recently, an active nano-signalling system was developed, in which one targeted nanomaterial triggers a local biological cascade that, in turn, recruits other therapeutic nanoparticles to the disease sit”