Addiction to Oncogenes--the Achilles Heal of Cancer

By I. Weinstein. Science, 2002

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MYC activation is a hallmark of cancer initiation and maintenance. (2014, background): “…models demonstrated a dependency on continuous MYC expression for tumor progression, the key challenge to understanding MYC oncogene addiction is the delineation of the mechanisms underlying this dependency (Weinstein 2002; Sharma and Settleman 2007; Felsher 2008; Weinstein and Joe 2008).”
MEK1 mutations confer resistance to MEK and B-RAF inhibition (2009, background): “When rendered constitutively active by genetic mutation, the MAP kinase pathway is believed to confer ‘‘oncogene dependency’’ (2), an excessive reliance on its dysregulated activity for tumor viability.”
Somatic mutations of the HER2 kinase domain in lung adenocarcinomas. (2005, background): “The promising results of these TK inhibitors invoke the concept of ‘‘oncogene addiction,’’ which hypothesizes that cancer cells are both transformed and physiologically dependent on activated oncogenes for their survival (8, 9).”