CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors.

By S. Shmelkov, J. Butler, A. Hooper, A. Hormigo, Jared S Kushner, T. Milde, Ryan M. St. Clair, Muhamed Baljevic, Ian A. White, D. Jin and 10 more. Journal of Clinical Investigation, 2008

976 citations recorded by the source corpus.

Subfields: Oncology

View Paper: https://www.semanticscholar.org/paper/97e649843f77d8f2491b41471fbecf83e91e8f11

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In Oncology

1. E. Batlle
2. M. Wicha
3. G. Dontu
4. Hans Clevers
5. C. Abate-Shen
6. M. Shen
7. R. Weinberg
8. Jane E. Visvader

Citations in the corpus

• SSEA-1 Is an Enrichment Marker for Tumor-Initiating Cells in Human Glioblastoma (2009, background): “In these studies, tumor cells expressing both CD133 and CD44 cells were not a significant population (Dalerba et al., 2007; Shmelkov et al., 2008), suggesting that there may exist more than one marker that can prospectively enrich for a TSC/TIC population.”
• Aldehyde Dehydrogenase 1 Is a Marker for Normal and Malignant Human Colonic Stem Cells (SC) and Tracks SC Overpopulation during Colon Tumorigenesis (2009, background): “However, it was subsequently reported that CD133 expression is not specific to SC in the colon, and both CD133+ and CD133− metastatic colon cancer cells can initiate xenograft tumors (8).”
• The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. (2011, result): “This localization is consistent with that described previously (Shmelkov et al., 2008).”
• Spherical Cancer Models in Tumor Biology (2015, neutral): “However, the latter spheres have also been termed “spheroids” [40], “colonospheres” [41,42], and more recently “colospheres” [43,44].”
• Identification of Gastric Cancer Stem Cells Using the Cell Surface Marker CD44 (2009, result): “For example, as recently reported [44], CD133 may not be a true marker for colon CSC, although two earlier studies independently described CD133 as a good CSC marker for colon cancer [13,14].”
• Molecular genetics of prostate cancer: new prospects for old challenges. (2010, background): “Two possible lineage relationships for the adult prostate epithelium are shown, together with the potential roles of Lin suggested for CD133 (Shmelkov et al. 2008).”