Clozapine treatment for suicidality in schizophrenia: International Suicide Prevention Trial (InterSePT).

By H. Meltzer, L. Alphs, A. Green, A. Altamura, R. Anand, A. Bertoldi, M. Bourgeois, G. Chouinard, M. Z. Islam, J. Kane and 78 more. Archives of General Psychiatry, 2003

1,353 citations recorded by the source corpus.

Subfields: Clinical Psychology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/97d0ebd04e3e564b2beac61a7c6221d1c8fdb040

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Citations in the corpus

Glutamate and Schizophrenia: Beyond the Dopamine Hypothesis (2006, background): “In addition, clozapine treatment has been associated with reduction in the rate of suicide, reduction in smoking and reduction in abuse of other substances in schizophrenic patients (Drake et al., 2000; Meltzer et al., 2003; Zimmet et al., 2000).”
The 2009 schizophrenia PORT psychopharmacological treatment recommendations and summary statements. (2010, positive): “to clozapine showed significantly less suicidal behavior over 2 years than those randomized to olanzapine.(85) A more recent meta-analysis of 6 studies(86) confirmed these findings and reported that clozapine treatment was associated with a 3-fold overall reduction in the risk of suicidal”
Suicide prevention strategies: a systematic review. (2005, background): “Randomized controlled trials can be informative when higher-risk patients are studied and indicate an antisuicidal effect for lithium in major mood disorders(34) and clozapine in schizophrenia.(32,33) Few studies prospectively identified suicidal behavior as an outcome measure and systematically ass”
Delay and failure in treatment seeking after first onset of mental disorders in the World Health Organization's World Mental Health Survey Initiative. (2007, background): “In addition, clinical trials have shown that timely intervention can prevent suicidality (12).”
Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the management of schizophrenia and related disorders (2016, background): “Clozapine is the only antipsychotic shown to reduce suicidal behaviour in people with schizophrenia (Hennen and Baldessarini, 2005; Meltzer et al., 2003).”
Trends in suicide ideation, plans, gestures, and attempts in the United States, 1990-1992 to 2001-2003. (2005, background): “Specifically, randomized controlled trials find only modest effects of treatment in reducing suicidality, even with optimal regimens.(36-40) Community studies of treatment quality consistently find that the majority of patients currently in treatment for mental disorders receive care that fails to m”
Failure and delay in initial treatment contact after first onset of mental disorders in the National Comorbidity Survey Replication. (2005, background): “Recent randomized clinical trials have shown that treatment can prevent suicidality.(80) Furthermore, most people with 1 disorder progress to develop comorbid disorders and such comorbidity is associated with an even more persistent and severe clinical course.”
Schizophrenia, "just the facts" 4. Clinical features and conceptualization. (2009, positive): “Treatment with clozapine in comparison to other antipsychotic agents may reduce the risk of suicide (Meltzer et al., 2003; Hennen and Baldessarini, 2005).”