MicroRNAs: small RNAs with a big role in gene regulation

By Lin He, Gregory J. Hannon. Nature reviews genetics, 2004

4,652 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9780c92e7f81fef3d417c142796a6ac2fc21302a

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Citations in the corpus

Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes. (2006, background): “…stem-loop structure and regulate gene expression through translational repression or mRNA cleavage (for reviews, see Ambros 2004; Bartel 2004; He and Hannon 2004; Du and Zamore 2005). siRNAs are generated from long double-stranded RNA (dsRNA) and are mainly involved in defense against molecular…”
Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. (2007, background): “miRNA expression patterns can be developmentally regulated, tissue specific, or steadily expressed in the whole organism (1, 2) and are considered to play important roles in cell proliferation, apoptosis, and differentiation (1, 2).”
Identification of 22 candidate structured RNAs in bacteria using the CMfinder comparative genomics pipeline (2007, neutral): “The following eight groups were used: (1) Firmicutes, (2) Actinobacteria, (3) a-proteobacteria, (4) b-proteobacteria, (5) g-proteobacteria, (6) d- and e-proteobacteria, (7) Cyanobacteria and (8) Bacteroidetes, Chlorobi, Chlamydiae, Verrucomicrobia and Spirochaetes.”
microRNA-directed phasing during trans-acting siRNA biogenesis in plants. (2005, background): “…most animal miRNAs and possibly *Correspondence: carrington@cgrb.oregonstate.edu some plant miRNAs function to repress expression at the translational or cotranslational level (Ambros, 2003; Aukerman and Sakai, 2003; Chen, 2004; He and Hannon, 2004; Olsen and Ambros, 1999; Seggerson et al., 2002).”
miR-19 is a key oncogenic component of mir-17-92. (2009, background): “Polycistronic gene structure is frequently observed in miRNA loci (Ambros 2004; He and Hannon 2004; Zamore and Haley 2005).”
1D and 2D annotation enrichment: a statistical method integrating quantitative proteomics with complementary high-throughput data (2012, background): “While transcriptional regulation is generally a dominant aspect of the entire expression cascade, there are many known examples of posttranscriptional regulation like micro-RNA controlled inhibition of transcripts [10] and directed protein degradation [11].”
Posttranscriptional Induction of Two Cu/Zn Superoxide Dismutase Genes in Arabidopsis Is Mediated by Downregulation of miR398 and Important for Oxidative Stress Tolerance[W] (2006, background): “…RNAs (siRNAs), the importance of posttranscriptional gene regulation is also widely recognized now. miRNAs are;21-nucleotide noncoding RNAs and are processed from hairpin precursors by the Dicer family of enzymes (Carrington and Ambros, 2003; Bartel, 2004; Baulcombe, 2004; He and Hannon, 2004).”
Normal microRNA Maturation and Germ-Line Stem Cell Maintenance Requires Loquacious, a Double-Stranded RNA-Binding Domain Protein (2005, neutral): “and repress cognate mRNA targets [1,2].”
An Endothelial-specific microRNA Governs Vascular Integrity and Angiogenesis (2008, background): “The miRNA strand of the heteroduplex becomes incorporated into the RNA-induced silencing complex (RISC), where it is enabled to target specific mRNAs through complementary sequences in 30 untranslated regions (He and Hannon, 2004).”
Regulation of Phosphate Homeostasis by MicroRNA in Arabidopsis[W] (2005, background): “The diverse expression patterns and large varieties of potential target genes of miRNAs suggest that miRNAs can regulate various developmental and physiological processes and might play a direct role in cell-tocell signaling in plants (Dugas and Bartel, 2004; He and Hannon, 2004; Yoo et al., 2004; K”
Plant microRNAs: new players in functional genomics (2013, neutral): “In plants, most miRNA genes are intergenic and transcribed individually from their own region, but a few genes are organized into polycistronic transcription units and cotranscribed from a single promoter at the end of a miRNA gene cluster (Bartel 2004; He and Hannon 2004; Voinnet 2009).”
MicroRNAs in Common Human Diseases (2012, background): “Whereas partial complementarity may induce translation repression or target mRNA instability, perfect complementarity normally causes target mRNA destruction [24].”
Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model (2010, background): “These small cellular RNAs bind to partially complementary sequences at the 3′ untranslated region (UTR) of specific target mRNA molecules, leading to the degradation of the target mRNAs or to the inhibition of their translation, or bot”