Functional small-diameter neovessels created using endothelial progenitor cells expanded ex vivo
By S. Kaushal, G. Amiel, K. Guleserian, O. Shapira, Tjorvi E Perry, Fraser Sutherland, E. Rabkin, A. Moran, F. Schoen, A. Atala and 3 more. Nature Medicine, 2001
878 citations recorded by the source corpus.
Subfields: Biomaterials, Molecular Biology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/977a5350335c849eba0ef845fd9e4af9a2390ccd
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In Biomaterials
Citations in the corpus
- The use of whole organ decellularization for the generation of a vascularized liver organoid (2011, methodology): “These decellularized aortas were seeded with endothelial progenitor cells and implanted into sheep, and the neovessels remained patent for more than 4 months.(2) However, effective decellularization of thicker organs and tissues has been very difficult to achieve due to inefficient penetration of th”
- The Tissue-Engineered Vascular Graft—Past, Present, and Future (2015, background): “Another study showed that only 10% of seeded EPCs remained present on a decellularized graft, after 130 days, implanted in the ovine carotid artery.(142) Additionally, studies in rats with PEUU grafts seeded with human pericytes found that most were lost from the graft after 8 weeks and replaced by ”
- Heart Valve Tissue Engineering: Concepts, Approaches, Progress, and Challenges (2006, background): “70 Mesenchymal stem cells (MSCs), have the potential for differentiating into osteogenic, chondrogenic, adipogenic, and myogenic lineages.”
- Engineering Complex Tissues (2006, neutral): “For example, in the cell-seeded scaffold model, a confluent endothelial coverage could be placed on a cardiovascular prosthesis at the time of implantation.(172,173) The cell transplant model used in experimental and early clinical trials of cell-based therapy for myocardial tissue repair uses cells”
- Stem cell plasticity: time for a reappraisal? (2005, neutral): “Autologous ovine EPC were also seeded on decellularized vessels and grafted into carotid arteries to generate non-thrombogenic functional vessels that remained patent with no occlusions for 120 days, in contrast to the endothelial-free vascular grafts that formed thrombi.(80) Thus, graft precoating ”