Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis.

By J. Bourhis, J. Overgaard, H. Audry, K. Ang, M. Saunders, J. Bernier, J. Horiot, A. le Maître, T. Pajak, M. Poulsen and 10 more. The Lancet, 2006

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An update on larynx cancer (2017, background): “0 Gy per fraction.(53) Hyperfractionated XRT is defined as the delivery of a greater total dose of radiation over the same time interval, usually 7 weeks.”
Normal tissue reactions to radiotherapy (2009, neutral): “Other approaches for improving therapeutic ratios include altering radiotherapy fractionation, for example the Conventional or Hypofractionated High Dose Intensity Modulated Radiotherapy in Prostate Cancer (CHHiP) trial and the European Organization for Research and Treatment of Cancer (EORTC) trial”
Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): a comprehensive analysis by tumour site. (2011, background): “This trend is significant on the overall database and was significant in the meta-analysis of fractionation in head and neck cancer [17].”
Single-cell landscape of peripheral and tumor-infiltrating immune cells in HPV-negative HNSCC (2025, unknown): “14-16 Despite advances in immunotherapies such as immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 pathway, therapeutic resistance remains a significant barrier.”