Normal tissue reactions to radiotherapy
By G. Barnett, C. West, Alison M. Dunning, R. Elliott, C. Coles, P. Pharoah, N. Burnet. Nature Reviews. Cancer, 2009
729 citations recorded by the source corpus.
A key challenge in radiotherapy is to maximize radiation doses to cancer cells while minimizing damage to surrounding healthy tissue. As severe toxicity in a minority of patients limits the doses that can be safely given to the majority, there is interest in developing a test to measure an individual's radiosensitivity before treatment. Variation in sensitivity to radiation is an inherited genetic trait and recent progress in genotyping raises the possibility of genome-wide studies to characterize genetic profiles that predict patient response to radiotherapy.
Subfields: Genetics, Pulmonary and Respiratory Medicine, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/1d8a55ed3ac95a7c754426d41d8be73f4b03d213
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In Genetics
In Pulmonary and Respiratory Medicine
In Radiology, Nuclear Medicine and Imaging
Citations in the corpus
- The global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012 (2017, background): “finding of a difference in the survival rate is not universally observed,(83) because type II and III nasopharyngeal cancers are more radiosensitive and may have better treatment outcomes than type I cancers.(82) Hypopharyngeal cancers are relatively uncommon in most parts of the world.”
- The emerging role of reactive oxygen and nitrogen species in redox biology and some implications for plasma applications to medicine and biology (2012, background): “Barnett et al [120] note that up to 50% of all cancer patients worldwide receive some form of this therapy.”