Three-dimensional cell culture: the missing link in drug discovery.

By Susan Breslin, Lorraine O'Driscoll. Drug Discovery Today, 2013

1,261 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/96e439088f40938688469bc21ffcdde55f0ea1a6

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Citations in the corpus

Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors (2014, methodology): “More detailed information about a number of commercially available 3D cell culture systems, their specific features, as well as advantages and disadvantages of each type of the above-mentioned methods can be found in two of the most recent reviews.(5,19) With each of these methods, cells grow natura”
Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning (2018, background): “, 1970) or gyratory rotation devices (Goodwin et al., 1993; Breslin and O’Driscoll, 2013) provide large-scale methods to generate 3D spheres but lack the possibility for miniaturization and are not compatible with HTS methods.”
Is It Time to Start Transitioning From 2D to 3D Cell Culture? (2020, background): “ECM molecules include matrix proteins, glycoproteins, glycosaminoglycans, proteoglycans, ECM-sequestered growth factors, vascular endothelial growth factor (VEGF), plateletderived growth factor (PDGF), hepatocyte growth factor (HGF) as well as other secreted proteins (Breslin and O’Driscoll, 2013).”
Current advances and future perspectives in extrusion-based bioprinting. (2016, methodology): “These methods include the hanging drop, pellet (re-aggregation) culture or conical tube, micro-molded (non-adhesive) hydrogels, microfluidics (hydrodynamic cell trapping), liquid overlay, spinner flask and rotating wall vessel techniques [168].”
2D and 3D cell cultures – a comparison of different types of cancer cell cultures (2016, background): “In adherent 2D cultures, cells grow as a monolayer in a culture flask or in a flat petri dish, attached to a plastic surface [10].”