Nonviral gene therapy: promises and challenges

By Song Li, Leaf Huang. Gene Therapy, 2000

623 citations recorded by the source corpus.

Subfields: Genetics, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/96b166a535f5da0ab73aa9d5dd03a3e43cb99ead

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In Molecular Biology

1. Shirui Mao
2. T. Kissel
3. Wei Sun

Citations in the corpus

• Gene delivery by lipoplexes and polyplexes. (2010, background): “Synthetic, non-viral vectors are potential alternatives to viral vectors, and may overcome several problems encountered in viral vector-mediated therapy, including immune responses, limited DNA carrying capacity, recombination and high cost (Li and Huang, 2000; Chesnoy and Huang, 2000; Harrington et”
• Chitosan-based formulations for delivery of DNA and siRNA. (2010, background): “Therefore, non-viral systems based on cationic polymers containing several amine groups in their backbone have been used extensively as gene carriers [7].”
• Uptake Pathways and Subsequent Intracellular Trafficking in Nonviral Gene Delivery (2006, background): “However, the comparatively low efficiency is a main disadvantage of nonviral vectors, and efforts are ongoing to increase their efficiency (Li and Huang, 2000).”