A Distinct Function of Regulatory T Cells in Tissue Protection
By Nicholas Arpaia, Jesse A. Green, Bruno Moltedo, Aaron Arvey, S. Hemmers, Shaopeng Yuan, P. Treuting, Alexander Y. Rudensky. Cell, 2015
903 citations recorded by the source corpus.
SUMMARY Regulatory T (Treg) cells suppress immune responses to a broad range of non-microbial and microbial antigens and indirectly limit immune inflammation-in-flicted tissue damage by employing multiple mechanisms of suppression. Here, we demonstrate that selective Treg cell deficiency in amphiregulin leads to severe acute lung damage and decreased blood oxygen concentration during influenza virus infection without any measureable alterations in Treg cell suppressor function, antiviral immune responses, or viral load. This tissue repair modality is mobilized in Treg cells in response to inflammatory mediator IL-18 or alarmin IL-33, but not by TCR signaling that is required for suppressor function. These results suggest that, during infectious lung injury, Treg cells have a major direct and non-redundant role in tissue repair and maintenance—distinct from their role in suppression of immune responses and inflammation—and that these two essential Treg cell functions are invoked by separable cues.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/9650b75c5c71802fe4e581bac56496b303df5902
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In Immunology
Citations in the corpus
- The role of macrophages in the resolution of inflammation. (2019, background): “For example, regulatory T cells that expand in the injured tissue can release amphiregulin, TGF-β, and IL-10, or directly interact with macrophages via ligand/surface interactions induced by CD40/CD80 (55).”
- Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells (2016, background): “…transcriptional signatures, because they can display functions beyond their wellestablished suppressive roles, such as metabolic modulation in adipose tissue (Cipolletta et al., 2012) or regulation of tissue repair in skeletal muscle (Burzyn et al., 2013) and in lung tissue (Arpaia et al., 2015).”
- Regulatory T cells in Skin Facilitate Epithelial Stem Cell Differentiation (2017, positive): “In addition, Tregs in muscle and lung express high levels of the epidermal growth factor ligand, amphiregulin, conferring the ability to mediate tissue protection and maintain barrier integrity (Arpaia et al., 2015; Burzyn et al., 2013; Villalta et al., 2014).”