Retinoic Acid Synthesis and Signaling during Early Organogenesis

By G. Duester. Cell, 2008

1,111 citations recorded by the source corpus.

Retinoic acid, a derivative of vitamin A, is an essential component of cell-cell signaling during vertebrate organogenesis. In early development retinoic acid functions as a trunk organizer by providing an instructive signal for posterior neuroectoderm and foregut endoderm and a permissive signal for trunk mesoderm differentiation. At later stages, retinoic acid contributes to the development of the eye and other organs. Recent efforts suggest that retinoic acid acts primarily in a paracrine manner and provide insight into the cell-cell signaling networks that control differentiation of pluripotent cells.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/964f9f0869ccf82c4d19d5d50b3b65716c132e8b

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In Molecular Biology

1. M. Griswold
2. Aaron M. Zorn
3. James M. Wells
4. M. Rhinn
5. R. Medzhitov
6. P. Dollé
7. Y. Okabe
8. Kevin J. Tracey

Citations in the corpus

• Vertebrate Endoderm Development and Organ Formation (2009, background): “RA has multiple roles regulating cell identity in the pharyngeal arches, the anterior and posterior ends of the foregut, as well as a posteriorizing role in the hindgut (Duester 2008).”
• Tissue-specific signals control reversible program of localization and functional polarization of macrophages. (2014, positive): “…the spleen and small intestine was comparable to that of mice bred on control diet 836 Cell 157, 832–844, May 8, 2014 ª2014 Elsevier Inc. transcriptional activation requires local conversion of these inactive vitamin A metabolites into biologically active retinoic acid (Duester, 2008; Gudas, 2012).”
• Spermatogenesis: The Commitment to Meiosis. (2016, background): “It has been suggested that RA may act primarily in a paracrine manner such that one cell stores retinol and oxidizes it to RA that then activates an adjacent target cell (33).”
• Retinoic acid signalling during development (2012, background): “Details of RA functions in other organ systems can be found in other reviews (Duester, 2008; Niederreither and Dollé, 2008).”