An Autophagy-Enhancing Drug Promotes Degradation of Mutant α1-Antitrypsin Z and Reduces Hepatic Fibrosis

By T. Hidvegi, Michael Ewing, P. Hale, C. Dippold, C. Beckett, Carolyn Kemp, N. Maurice, A. Mukherjee, C. Goldbach, Simon C Watkins and 2 more. Science, 2010

600 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/95f2c176e1f630293ac27dd8a3df9b769ec3edc0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. M. Komatsu
2. N. Mizushima
3. R. Kaufman
4. Beth Levine
5. I. Slaninová
6. Alec C. Kimmelman
7. D. Klionsky
8. Guido Kroemer

In Molecular Biology

1. M. Komatsu
2. N. Mizushima
3. R. Kaufman
4. H. Malhi
5. Beth Levine
6. D. Klionsky
7. E. White
8. I. Slaninová

In Physiology

1. N. Mizushima
2. M. Komatsu
3. R. Kaufman
4. Beth Levine
5. I. Slaninová
6. E. White
7. Guido Kroemer
8. Alec C. Kimmelman

Citations in the corpus

• Autophagy: Renovation of Cells and Tissues (2011, background): “A recent study demonstrated that an autophagy-activating drug, carbamazepine , decreases the amount of the mutant protein and ameliorates hepatic fibrosis in a mouse model of a 1 -antitrypsin deficiency (Hidvegi et al., 2010).”
• Endoplasmic Reticulum Stress in Liver Disease (2010, background): “This was recently demonstrated in cell culture and mouse models using carbamazepine to enhance autophagy [48].”