Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

8,197 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

The transcription factor PLZF (Zbtb16) directs the effector program of the NKT cell lineage (2008, background): “Cells were then washed and blocked with goat serum (Southern Biotech), washed again and fixed with the permeabilization and fixation buffer ‘‘Foxp3 Staining Buffer Set’’ from eBioscience.”
Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection. (2007, background): “Foxp3, a critical regulator of the development and function of Tregs, fulfills the criteria of a Treg-specific marker.(5,13,14) It was reported that high Foxp3 expression is associated not only with dismal prognosis in ovarian cancer but also represents an independent predictor for overall survival ”
FOXP3 controls regulatory T cell function through cooperation with NFAT. (2006, neutral): “There is compelling evidence thatFOXP3 servesas alineage spec-iﬁcation factor for regulatory T cells, a class of T cells that develops primarily in the thymus and is essential for maintaining self-tolerance (Fontenot et al., 2003; Hori et al., 2003; Khattri et al., 2003).”