Intimate bacterial–fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans

By V. Schroeckh, K. Scherlach, Hans-Wilhelm Nützmann, E. Shelest, W. Schmidt-Heck, J. Schuemann, K. Martin, C. Hertweck, Axel A. Brakhage. Proceedings of the National Academy of Sciences of the United States of America, 2009

656 citations recorded by the source corpus.

Subfields: Pharmacology, Plant Science

View Paper: https://www.semanticscholar.org/paper/958fa78784ac1556a1c4006f8ebe75992f820bfd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Pharmacology

1. P. Proksch
2. A. Debbab
3. A. Aly
4. A. Varma
5. G. Berg
6. K. D. Hyde
7. Liang-Dong Guo
8. T. Suryanarayanan

In Plant Science

1. M. Barret
2. K. Seem
3. P. Frey-Klett
4. A. Varma
5. Martin Grube
6. G. Berg
7. P. Chauhan
8. S. M. DasGupta

Citations in the corpus

• Tripartite interactions among Paenibacillus lentimorbus NRRL B-30488, Piriformospora indica DSM 11827, and Cicer arietinum L. (2010, background): “... (Table 1). The most efficient treatment in terms of plant height, dry weight, was the B-30488 followed by consortium, and DSM 11827 over uninoculated control (Table 1). Interesting observation was the ability of B-30488, DSM 11827 and consortium to enhance the nodulation ability by native chickp”
• Microbial consortia of bacteria and fungi with focus on the lichen symbiosis (2009, positive): “…research showed that cocultivation with actinomycetes can activate expression of hitherto unknown biosynthetic pathways in Aspergillus nidulans (Schroeckh et al., 2009), including the archetypal compound orsellinic acid, the typical lichen compounds lecanoric acid, and the cathepsin K…”
• Fungal endophytes: unique plant inhabitants with great promises (2011, background): “Competition among different fungi or among endophytic fungi and endophytic bacteria within a plant organ may also trigger natural product accumulation (Cueto et al. 2001; Ho et al. 2003; Oh et al. 2007; Glauser et al. 2009; Pettit 2009; Schroeckh et al. 2009).”
• Fungal endophytes from higher plants: a prolific source of phytochemicals and other bioactive natural products (2010, background): “…product production by cultured endophytes Recent gene sequencing studies of biogenetic gene clusters involved in fungal secondary metabolism suggest that the potential number of expected natural products exceeds by far the one known today (Szewczyk et al. 2008; Pettit 2009; Schroeckh et al. 2009).”
• Bacterial-Fungal Interactions: Hyphens between Agricultural, Clinical, Environmental, and Food Microbiologists (2011, background): “(353) demonstrated that the specific BFI between Aspergillus nidulans and Streptomyces hygroscopicus ATCC 29253 induces the expression of a fungal gene cluster responsible for the biosynthesis of several polyketide metabolites, including orsellinic acid and lecanoric acid, the latter being a typical”