Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer.

By R. Gryfe, Hyeja Kim, E. Hsieh, M. Aronson, E. Holowaty, S. Bull, M. Redston, S. Gallinger. New England Journal of Medicine, 2000

1,370 citations recorded by the source corpus.

Subfields: Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/95804d3bbc0542faf1c77f6dd2a28354c0dd35e9

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Citations in the corpus

Microsatellite instability in colorectal cancer—the stable evidence (2010, background): “Several population-based studies have reported that the prevalence of MSI in CRC ranges from 8% to 20%, although these values might differ according to tumor stage distribution”
Comprehensive Characterization of Cancer Driver Genes and Mutations (2018, background): “MSI cases show improved response to immune checkpoint therapy, independent of histology (Brahmer et al., 2012; Gryfe et al., 2000; Le et al., 2015).”
IARC Handbooks of Cancer prevention (2003, background): “, 2004), although, stage for stage, they have a better prognosis compared with non-MSI-H tumours (Gryfe et al., 2000); more recently, evidence has emerged that metastatic MSI-H tumours respond well to immune checkpoint inhibitors (Le et al.”
Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. (2001, neutral): “Approximately 90% of colon carcinomas with MSI have inactivating mutations of TRII (Parsons et al., 1995), and MSI is significantly correlated with a reduced incidence of metastases and increased patient survival ( Gryfe et al., 2000; Thibodeau et al., 1993), suggesting that complete loss of TRII i”
Tumor-infiltrating lymphocytes in the immunotherapy era (2020, result): “Like reaction (CLR)’, have better OS than CRC patients who exhibit only diffuse inflammatory infiltration (DII).131,132 Accordingly, the existence of immune infiltrates in TLSs at the invasive margin was associated with a decreased presence of early metastatic processes such as vascular, lymphatic, ”
Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications (2009, background): “The basis for such a survival advantage remains elusive; this advantage is also seen in CRC patients with MSI that is not due to LS (29, 31, 58).”
Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer. (2010, methodology): “MSI Analysis Extracted DNA from specimens from the GIVIO trial, and for all patients included from the report by Ribic et al,(20) were amplified by polymerase chain reaction by using two to 11 microsatellite markers, as described previously.(16) Tumor samples were classified as displaying high-frequ”