Mutational effects on stability are largely conserved during protein evolution

By Orr Ashenberg, L. Gong, Jesse D. Bloom. 2013

134 citations recorded by the source corpus.

Subfields: Materials Chemistry, Molecular Biology

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Citations in the corpus

Coevolutionary Landscape Inference and the Context-Dependence of Mutations in Beta-Lactamase TEM-1 (2015, background): “However, epistatic effects are not equally important for all residues, which may explain that some authors disagree on the contribution of the sequence context to mutational effect [13, 66, 67].”
Selection for Protein Stability Enriches for Epistatic Interactions (2018, background): “, [14,19], can only determine the extent of epistasis at that one level of divergence.”
Accurate Measurement of the Effects of All Amino-Acid Mutations on Influenza Hemagglutinin (2016, background): “However, many aspects of mutational effects are often roughly conserved during evolutionary divergence: for instance, experiments have shown that the effects of mutations on stability are often quite similar among homologs, both for HA [45] and proteins more generally [46,47].”
Epistasis in protein evolution (2016, background): “observed when epistasis is experimentally characterized in real proteins? Two studies have experimentally measured the effects on folding stability of a handful of mutations when introduced into divergent orthologs, which differ at up to 28% and 43% of sites.(8,9) Both studies found that it is rare ”
Merging molecular mechanism and evolution: theory and computation at the interface of biophysics and evolutionary population genetics (2014, background): “For example, some groups are now examining the validity of some central assumptions in molecular evolution such as the site-independence of substitution models [83,84].”
Epistasis and the Dynamics of Reversion in Molecular Evolution (2016, background): “…clarity to a recent controversy concerning site-specific amino acid preferences during protein evolution (Pollock et al. 2012; Naumenko et al. 2012; Ashenberg et al. 2013; Pollock and Goldstein 2014; Risso et al. 2015; Goldstein et al. 2015; Shah et al. 2015; Usmanova et al. 2015; Bazykin 2015).”