Abstract 3019: Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells

By Hyun-soo Cho, Takehiro Suzuki, N. Dohmae, S. Hayami, M. Unoki, Masanori Yoshimatsu, G. Toyokawa, M. Takawa, Taiping Chen, Julia K. Kurash and 4 more. 2011

207 citations recorded by the source corpus.

Subfields: Molecular Biology

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Citations in the corpus

Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway. (2011, methodology): “In Vitro Binding Assay The in vitro binding assay was described previously [33].”
Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN (2015, methodology): “Fixed cells were incubated with each primary antibody overnight at 4°C followed by incubation with Alexa Fluor–conjugated secondary antibody (Life Technologies, Carlsbad, CA) [23,24] and observed using Leica confocal microscopy (SP5 Tandem Scanner Spectral 2-Photon Confocal).”
Enhanced expression of EHMT2 is involved in the proliferation of cancer cells through negative regulation of SIAH1. (2011, methodology): “Immunohistochemical Staining and Tissue Microarray Immunohistochemical analysis was performed using a specific polyclonal rabbit-EHMT2 antibody as described previously [23,24].”
Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B (2012, unknown): “IB: HA (AURKB) HA–AURKB – – + – + – FLAG–AURKB-[1-200] FLAG–AURKB-[201-344]”
WHSC1 Promotes Oncogenesis through Regulation of NIMA-Related Kinase-7 in Squamous Cell Carcinoma of the Head and Neck (2014, background): “Mol Cancer Res; 13(2) February 2015 Molecular Cancer Research 300”
SUV39H2 methylates and stabilizes LSD1 by inhibiting polyubiquitination in human cancer cells (2015, methodology): “In vivo labeling was performed as described previously [51].”
The histone methyltransferase Wolf–Hirschhorn syndrome candidate 1‐like 1 (WHSC1L1) is involved in human carcinogenesis (2013, methodology): “The statistical procedure for micaroarray analysis was described preciously (Hayami et al., 2010, 2011; Cho et al., 2011a; Yoshimatsu et al., 2011).”
RB1 methylation by SMYD2 enhances cell cycle progression through an increase of RB1 phosphorylation. (2012, methodology): “After boiling in sample buffer, the samples were subjected to SDS-PAGE, followed by visualization by fluorography [25].”
The JmjC domain‐containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene (2012, methodology): “Cells were transfected with FuGENE6 (Roche Applied Science, Penzberg, Germany) according to manufacturer’s protocols.(30,31)”
Deregulation of the Histone Lysine-Specific Demethylase 1 Is Involved in Human Hepatocellular Carcinoma (2019, background): “We previously reported that LSD1 is overexpressed in various types of human cancers and promotes malignant behavior [25,41].”
SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation. (2014, methodology): “293T cells were co-transfected with a FLAGSMYD2 expression vector and four different lengths of HA-HSP90AB1 vectors ([1–724], [1–500], [250–724] and [500–724]).”