Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors
By R. Kalaria, Gladys E. Maestre, R. Arizaga, R. Friedland, D. Galasko, K. Hall, José A. Luchsinger, A. Ogunniyi, E. Perry, F. Potocnik and 5 more. Lancet Neurology, 2008
1,153 citations recorded by the source corpus.
Despite mortality due to communicable diseases, poverty, and human conflicts, dementia incidence is destined to increase in the developing world in tandem with the ageing population. Current data from developing countries suggest that age-adjusted dementia prevalence estimates in 65 year olds are high (≥5%) in certain Asian and Latin American countries, but consistently low (1–3%) in India and sub-Saharan Africa; Alzheimer's disease accounts for 60% whereas vascular dementia accounts for ∼30% of the prevalence. Early-onset familial forms of dementia with single-gene defects occur in Latin America, Asia, and Africa. Illiteracy remains a risk factor for dementia. The APOE ε4 allele does not influence dementia progression in sub-Saharan Africans. Vascular factors, such as hypertension and type 2 diabetes, are likely to increase the burden of dementia. Use of traditional diets and medicinal plant extracts might aid prevention and treatment. Dementia costs in developing countries are estimated to be US$73 billion yearly, but care demands social protection, which seems scarce in these regions.
Subfields: Neurology, Physiology, Psychiatry and Mental health
View Paper: https://www.semanticscholar.org/paper/94ff6ac108cc105c578f838df2f814c1dfac976c
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Citations in the corpus
- The Role of Apolipoprotein E in Alzheimer’s Disease (2009, neutral): “ethnic groups, the APOE 34 allele seems to have either a weaker effect or no clear effect on AD (Farrer et al., 1997; Kalaria et al., 2008; Mayeux, 2003; Tang et al., 1998).”
- Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention (2009, background): “The long-term institutional care will be the main cost in many developed countries, whereas in developing countries informal home care provided by family members is usually the only source available for patients with dementia.(12) Even in the US, almost 10 million Americans (eg, family members, frie”
- Oxidative Stress and the Pathogenesis of Alzheimer's Disease (2013, background): “…Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China Correspondence should be addressed to Yan Zhao; ywz12@yahoo.com and Baolu Zhao; zhaobl@sun5.ibp.ac.cn Received 25 May 2013; Accepted 3 July 2013 Academic Editor: Cláudio M. Gomes Copyright © 2013 Y. Zhao and B. Zhao.”