Interaction of polycationic polymers with supported lipid bilayers and cells: nanoscale hole formation and enhanced membrane permeability.

By Seungpyo Hong, P. Leroueil, E. Janus, J. Peters, M. Kober, M. Islam, B. Orr, J. Baker, M. M. Banaszak Holl. Bioconjugate chemistry, 2006

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Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways. (2008, background): “The cationic charge on the particle surface is likely responsible for the initial binding to the surface membrane, as suggested by previous findings that polyamine-PS microparticles engage in strong ionic interactions with the negatively charged cell membrane.(24) Particle uptake by this mechanism i”
Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles. (2008, background): “To establish whether ‘striped’ nanoparticles penetrate cell membranes through creation of transient holes, we tested whether the internalization of ligand-protected nanoparticles was accompanied by escape of cytosol-localized tracer dye or conversely, cytosolic entry of an initially extracellular tr”