Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.

By S. Matsuzawa, John Calvin Reed. Molecules and Cells, 2001

629 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/94aed1e9c2bb5a0054184aea97bd02f1df44742e

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Citations in the corpus

GSK3 takes centre stage more than 20 years after its discovery. (2001, background): “42 Seidensticker, M. J. and Behrens, J. (2000) Biochemical interactions in the wnt pathway.”
β-Catenin destruction complex: insights and questions from a structural perspective (2006, background): “Oncogene Intriguingly, the E2-ligase-binding protein Siah-1 binds the C-terminus of APC and promotes the ubiquitination of b-catenin in a GSK3-independent process (Liu et al., 2001a; Matsuzawa and Reed, 2001).”
NF‐κB and the link between inflammation and cancer (2012, background): “Moreover, whereas IjB degradation relies exclusively on b-TrCP, b-catenin can be selectively targeted for degradation by other E3 ligases, independent of b-TrCP (205, 206).”
The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway (2003, background): “…of data includes the steady state flux m11 for the degradation of b-catenin via the Wnt pathway and the flux ratio m13 / m11 describing the extent to which b-catenin is degraded via non-Wnt mechanisms (e.g., via Siah-1 and presenilin [Liu et al. 2001; Matsuzawa and Reed 2001; Kang et al. 2002]).”
The many faces and functions of β‐catenin (2012, positive): “This mechanism does not require a preceding phosphorylation of b -catenin, but it does involve APC acting in a scaffolding role as it does in the classical b -catenin degradation machinery (Matsuzawa and Reed, 2001; Dimitrova et al , 2010).”
Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation (2003, background): “It has also been shown that both phosphorylated and unphosphorylated -catenin can be targeted for proteasomemediated degradation through an alternative E3 ubiquitin ligase complex that contains APC, Ebi, and Siah1 or 2 (Liu et al., 2001; Matsuzawa and Reed, 2001).”