Third-Generation Biomedical Materials

By L. Hench, J. Polak. Science, 2002

2,614 citations recorded by the source corpus.

Subfields: Biomedical Engineering

View Paper: https://www.semanticscholar.org/paper/9476fbb2e0dfb79ed017f076774289fa8b362156

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. Julian R. Jones
2. J. Gough
3. I. Sabree
4. Aldo R. Boccaccini
5. Chengtie Wu
6. K. Rezwan
7. T. Vladkova
8. L. Gerhardt

Citations in the corpus

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• Bioactive Glass and Glass-Ceramic Scaffolds for Bone Tissue Engineering (2010, background): “It is now widely accepted that for establishing bond with bone, such a biologically active apatite surface layer must form at the material/bone interface [1,8,11,12,37] (see also discussion in §4).”
• Biomaterials in orthopaedics (2008, background): “…evolution of biomaterials research and their clinical availability during the last 60 years, three different generations seem to be clearly marked (Hench & Polak 2002): bioinert materials (first generation), bioactive and biodegradable materials (second generation), and materials designed to…”
• Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. (2006, background): “This period was soon followed by the development of biodegradable materials for bone tissue engineering scaffolds that can stimulate specific cellular responses at the molecular level [23].”
• Mechanical properties of porous ceramic scaffolds: Influence of internal dimensions (2015, background): “Various studies have determined that ionic dissolution products from bioactive glasses can enhance osteogenesis by activating genes found in osteoblasts and stimulating regeneration of bone tissue [19–21].”
• Harnessing nanotopography and integrin-matrix interactions to influence stem cell fate. (2014, background): “part, by mechanical interactions with the extracellular environment [21, 82, 110].”
• Surface Engineered Polymeric Biomaterials with Improved Biocontact Properties (2010, background): “Now material scientists have shifted toward the design of bioactive materials that integrate with biological molecules or cells and regenerate tissue [4–6].”