hERG potassium channels and cardiac arrhythmia
By Michael Sanguinetti, Martin Tristani-Firouzi. Nature, 2006
1,535 citations recorded by the source corpus.
Subfields: Cardiology and Cardiovascular Medicine, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/946cd7fa069abf4b21801c4531cb55a9d1bc65ee
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cardiology and Cardiovascular Medicine
- Hua-rong Lu
- Alfonso Bueno-Orovio
- Blanca Rodríguez
- Jeffrey J. Gray
- Adam P. Hill
- R. Greig
- Jamie I. Vandenberg
- Oliver J. Britton
In Molecular Biology
- Jeffrey J. Gray
- Julia Koehler Leman
- Jens Meiler
- Hua-rong Lu
- Alfonso Bueno-Orovio
- Blanca Rodríguez
- Adam P. Hill
- Sandeepkumar Kothiwale
Citations in the corpus
- Voltage-gated Potassium Channels as Therapeutic Drug Targets (2009, neutral): “1 that allows entry of a wide range of molecules of varying sizes and shape”
- Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity (2017, background): “The wide range of conductances considered includes extreme up- or downregulation of ion channels, which can be linked to specific mutations or diseased conditions known to be pro-arrhythmic (Sanguinetti and Tristani-Firouzi, 2006; Itoh et al., 2016; Wang et al., 2016).”
- Compilation and physicochemical classification analysis of a diverse hERG inhibition database (2016, neutral): “On the contrary, interactions with phenylalanine at position 656 are purely hydrophobic, as aromaticity is not absolutely required at this site [2, 8].”
- Computational modeling of membrane proteins (2014, positive): “140 This inhibition has led the pharmaceutical industry to use hERG as an antitarget to probe drug safety.”
- Computational Methods in Drug Discovery (2014, background): “The QT interval is the period of a cardiac cycle where ventricular repolarization occurs (Sanguinetti and Tristani-Firouzi, 2006), and drug-induced QT syndrome can lead to sudden death (Keating and Sanguinetti, 1996).”
- hERG K(+) channels: structure, function, and clinical significance. (2012, background): “IV for more detail of gating), makes the current passed through IKr channels ideally suited for determining the duration of the plateau phase of the action potential (AP) in atrial and ventricular myocytes (550, 583).”