Mechanisms Linking Circadian Clocks, Sleep, and Neurodegeneration
By E. Musiek, D. Holtzman. Science, 2016
771 citations recorded by the source corpus.
Disruptions of normal circadian rhythms and sleep cycles are consequences of aging and can profoundly affect health. Accumulating evidence indicates that circadian and sleep disturbances, which have long been considered symptoms of many neurodegenerative conditions, may actually drive pathogenesis early in the course of these diseases. In this Review, we explore potential cellular and molecular mechanisms linking circadian dysfunction and sleep loss to neurodegenerative diseases, with a focus on Alzheimer’s disease. We examine the interplay between central and peripheral circadian rhythms, circadian clock gene function, and sleep in maintaining brain homeostasis, and discuss therapeutic implications. The circadian clock and sleep can influence a number of key processes involved in neurodegeneration, suggesting that these systems might be manipulated to promote healthy brain aging.
Subfields: Cognitive Neuroscience, Endocrine and Autonomic Systems, Experimental and Cognitive Psychology
View Paper: https://www.semanticscholar.org/paper/9444de819403464601cef9b4f69c49f3ea60f681
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In Cognitive Neuroscience
In Endocrine and Autonomic Systems
In Experimental and Cognitive Psychology
Citations in the corpus
- New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation (2018, background): “Proposed effects of melatonin on mechanisms linking circadian clocks, sleep and neurodegeneration in AD (adapted from Landry and Liu-Ambrose, 2014; Musiek and Holtzman, 2016).”