Regulation of mast-cell and basophil function and survival by IgE

By T. Kawakami, S. Galli. Nature reviews. Immunology, 2002

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Mast cell-orchestrated immunity to pathogens (2010, background): “Subsequently, mast cells can become activated, resulting in degranulation following receptor cross-linking by polyvalent antige”
Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data (2007, background): “Exposure of murine mast cells to high levels of IgE in the absence of specific antigen resulted in increased surface expression of FceRI and, subsequently, increased mediator release after crosslinking of surface-bound IgE by allerge”
IgE in allergy and asthma today (2008, background): “This subject is discussed in greater detail in two recent review”
New developments in mast cell biology (2008, background): “Phospholipase C-γ can be activated through the coordinated function of the adaptor molecules Lat, Gads, SLP-76 and Vav and the tyrosine kinase Btk or independently of Lat through a PI(3)K-Btk–dependent pathway.”
Mast cells in the development of adaptive immune responses (2005, background): “Mast cell development, proliferation and phenotype Mast cells are derived from hematopoietic stem cells, but mast cells do not ordinarily circulate in mature form; instead, they undergo the terminal stages of their differentiation and/or maturation locally, after the migration of their precursors”