Safety criteria for transcranial direct current stimulation (tDCS) in humans.

By Michael A. Nitsche, David Liebetanz, N. Lang, Andrea Antal, F. Tergau, Walter Paulus. Clinical Neurophysiology, 2003

734 citations recorded by the source corpus.

Subfields: Anesthesiology and Pain Medicine, Neurology

View Paper: https://www.semanticscholar.org/paper/93b0e7df57283495e7a17edb5fcd578c50b1f726

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In Anesthesiology and Pain Medicine

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In Neurology

Citations in the corpus

Transcranial direct current stimulation: A computer-based human model study (2007, background): “However, one could clearly implement electrode montages that could influence brain stem activity, although this has been discouraged due to safety reasons (Nitsche et al., 2003).”
Transcranial DC stimulation (tDCS): a tool for double-blind sham-controlled clinical studies in brain stimulation. (2006, background): “…direct current stimulation (tDCS) influences cognitive functions in healthy volunteers (Antal et al., 2004; Fregni et al., 2005a; Iyer et al., 2005; Nitsche et al., 2003a) and transiently enhances motor performance in patients with chronic stroke (Hummel et al., 2005a; Hummel and Cohen, 2005;…”
Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines (2017, background): “The first evaluation of tDCS-induced AEs summarized data from approximately 500 healthy subjects between 2000 and 2003 (Nitsche et al., 2003).”
Effects of transcranial direct current stimulation on working memory in patients with Parkinson's disease (2006, methodology): “This procedure allowed to blind subjects for the respective stimulation condition [8] and has been described as reliable by a recent double-blind tDCS study [13].”
Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke. (2005, background): “In both sessions, currents were turned off slowly over a few seconds, a procedure that does not elicit perceptions (Nitsche et al., 2003c) and that was implemented out of the field of view of the patients.”
Stimulating Creativity: Modulation of Convergent and Divergent Thinking by Transcranial Direct Current Stimulation (tDCS) (2015, background): “Anodal stimulation is believed to increase excitability in the targeted brain region while cathodal stimulation reduces excitability (Nitsche et al., 2003; Priori, 2003).”
Rehabilitation of Motor Function after Stroke: A Multiple Systematic Review Focused on Techniques to Stimulate Upper Extremity Recovery (2016, positive): “Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) influence the function of the corticospinal tracts by modulating the corticomotor excitability (Nitsche and Paulus, 2000, 2001; Hummel and Cohen, 2006).”
Safety of transcranial Direct Current Stimulation: Evidence Based Update 2016 (2016, background): “Though methodology and rigor for reporting adverse events in tDCS are inconsistent across studies [53], [54], [55], [29], [56], [57], [58], [59], [60] human trials (per IRB guidance) should have specifically designed safety monitoring and reporting.”
Therapeutic effects of non-invasive brain stimulation with direct currents (tDCS) in neuropsychiatric diseases (2014, neutral): “The resulting plasticity involves glutamatergic 96 synapses, and is calcium-dependent (Nitsche et al., 2003a, 2004b; 97 Stefan et al., 2002; Wolters et al., 2003).”
Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory (2005, background): “…of excitability-enhancing anodal DC stimulation on simple reaction times and implicit motor learning when the primary motor cortex was stimulated (Nitsche et al. 2003c), as well as improved learning of a visuo-motor coordination task by stimulation of the primary motor area or the visual area V5…”
Increasing Human Brain Excitability by Transcranial High-Frequency Random Noise Stimulation (2008, background): “5 A/cm 2 over the motor cortex, which is below the safety parameters accepted for tDCS (Nitsche et al., 2003).”