A duplicated copy of DMRT1 in the sex-determining region of the Y chromosome of the medaka, Oryzias latipes

By I. Nanda, M. Kondo, U. Hornung, S. Asakawa, Christoph Winkler, A. Shimizu, Z. Shan, T. Haaf, N. Shimizu, A. Shima and 2 more. Proceedings of the National Academy of Sciences of the United States of America, 2002

828 citations recorded by the source corpus.

Subfields: Genetics, Reproductive Medicine

View Paper: https://www.semanticscholar.org/paper/93916925b232936345ac4e2080014b9f35ca8a0c

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Citations in the corpus

Fish Gonadogenesis. Part II: Molecular Biology and Genomics of Sex Differentiation (2008, background): “Duplication of dmrt1 gave rise to the sex-determining gene in medaka (Matsuda et al., 2002; Nanda et al., 2002).”
Sex Control in Fish: Approaches, Challenges and Opportunities for Aquaculture (2015, neutral): “sex-determining genes have been isolated in fish thus far, including PG17: DM-domain gene on the Y chromosome (dmY), the major testis-determining factor in the Japanese medaka (Oryzias latipes) (XX-XY) [47,48] anti-Müllerian hormone (amhY) and anti-Müllerian hormone receptor, type II (amhr2) in the ”
Sex determination and gonadal development in mammals. (2007, background): “The most direct evidence for an important role for Dmrt1 has come from studies in the model fish medaka (Oryzias latipes), where a related gene DMY (or Dmrt1bY) has been definitively identified as the primary, Y-linked sex-determining gene (147, 166).”
Sexual determination and differentiation in teleost fish (2010, background): “In addition, a functional copy of this gene named DMY is found in the Y chromosome, and has been proposed as the sex determining gene of this species (Matsuda et al. 2002; Nanda et al. 2002).”
Evolution of alternative sex-determining mechanisms in teleost fishes (2006, background): “…copies of DMRT1 may also assume a role of apical initiator in sex determination in some species such as O. latipes, where DMY (a recent duplicate of the DMRT1 gene; Lutfalla et al., 2003) is thought to be the initiating switch in male sex determination (Matsuda et al., 2003; Nanda et al., 2003).”
Revisiting the Impact of Inversions in Evolution: From Population Genetic Markers to Drivers of Adaptive Shifts and Speciation? (2008, background): “However, inversions do not appear to contribute to recombination suppression between homomorphic sex chromosomes in medaka fishes, although local duplications may contribute to reductions in recombination (Nanda et al. 2002).”
Steps in the evolution of heteromorphic sex chromosomes (2005, background): “It contains a gene, dmrt1bY, which is required for male development (Matsuda et al, 2002; Nanda et al, 2002).”
Fish Gonadogenesis. Part I: Genetic and Environmental Mechanisms of Sex Determination (2008, methodology): “Positional cloning of the sex determination region was carried out by isolating four BAC clones spanning the region between two markers flanking this region (the r locus and SL-1), then sequencing and analyzing these BAC clones (Matsuda et al., 2002; Nanda et al., 2002).”