High-throughput oncogene mutation profiling in human cancer

By Roman K. Thomas, Alissa C. Baker, R. Debiasi, W. Winckler, T. LaFramboise, William M. Lin, Meng Wang, Whei Feng, T. Zander, L. Macconaill and 43 more. Nature Genetics, 2007

1,054 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/938cffa833acf5f68e100110bc767454a172a42f

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In Cancer Research

In Genetics

In Pulmonary and Respiratory Medicine

Citations in the corpus

Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways (2008, background): “Conclusions Distinct cancer subtypes are associated with stereotypical genetic alterations (30), suggesting that the cell of origin of a cancer dictates, in part, the pathways that must be altered mutationally to achieve malignancy.”
Subtype-specific genomic alterations define new targets for soft tissue sarcoma therapy (2010, neutral): “To eliminate artifacts, false positives or germline mutations, candidate mutations were independently confirmed in tumor and matched normal samples with mass spectrometry–based genotypin”
Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling. (2011, methodology): “Key points using multibase hME extension chemistry by methods described previously.(62,63)”
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. (2007, positive): “Recent large-scale cancer sequencing efforts (Greenman et al., 2007; Thomas et al., 2007) have identified mutations in the activation loop of many of these kinases, suggesting roles as disease drivers.”
The emerging mechanisms of isoform-specific PI3K signalling (2010, background): “, as well as large-scale sequencing efforts of cancer genome”
Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients (2008, background): “Notwithstanding this close relationship, cancer genome sequencing experiments have uncovered a multiplicity of mutated gene products that derive from defects in tumor cell DNA repair mechanisms (30, 31).”
A Landscape of Driver Mutations in Melanoma (2012, methodology): “accompanying normal tissue was performed as previously described (Stransky et al., 2011; Thomas et al., 2007).”
Network modeling links breast cancer susceptibility and centrosome dysfunction. (2007, methodology): “Here we propose a complementary approach to systematic resequencing effort”
An Integrative Genomic and Proteomic Analysis of PIK3CA, PTEN, and AKT Mutations in Breast Cancer (2008, methodology): “A mass spectroscopy–based approach using methods designed to detect SNPs (11, 12) was used to detect the AKT1_E17K mutation, mutations in the equivalent sites of AKT2 and AKT3 , and mutations in PIK3CA in 547 breast cancers, primarily from Caucasian and Hispanic patients, and 41 cell lines (Table 1)”
Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics. (2009, background): “PIK3CA, KRAS , and E17K mutations in the AKT1/2/3 genes (12, 20).”
FastUniq: A Fast De Novo Duplicates Removal Tool for Paired Short Reads (2012, background): “NGS has been used in a wide range of research areas over the past few years such as determining whole-genome sequences for new species [1,2], addressing evolutionary processes at a genomic scale in natural populations [3], identifying mutant alleles in oncogenes in human cancers [4], and resolving w”