Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition

By Alysson Renato Muotri, V. Chu, M. Marchetto, Wei Deng, J. V. Moran, Fred H. Gage. Nature, 2005

913 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/92965ee71a8014729da012340444fa6a7c823a98

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Citations in the corpus

Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis (2009, neutral): “These findings are extended to the regulation of LINE-1 retrotransposon expression through silencing and activation of Sox2 and Wnt/β-catenin, respectively, which is consistent with LINE-1 being critical during neuronal differentiatio”
Cellular heterogeneity: when do differences make a difference? (2010, background): “Here, we have sidestepped the difficult and fascinating problems of identifying the origins of cellular heterogeneity (Brock et al., 2009; Muotri et al., 2005; Raj and c. van Oudenaarden, 2008; Spencer et al., 2009), or understanding its differences in vivo and in vitro or in physiological and…”
Transposition Driven Genomic Heterogeneity in the Drosophila Brain: A Dissertation (2012, neutral): “24 Prior work in mammals suggests that L1 expression occurs in neurons because the L1-promoter is released during neurogenesis (Muotri et al, 2005; Muotri et al., 2010).”
Environmental Influence on L1 Retrotransposons in the Adult Hippocampus (2009, methodology): “…dogma that neurons share identical genomes was recently challenged by the finding that adult neural stem cells isolated from rat hippocampus can give rise to neuronal progenitor cells (NPCs) that support LINE-1 (Long Interspersed Nuclear Elements 1 or L1) retrotransposition (Muotri et al., 2005).”
The impact of retrotransposons on human genome evolution (2009, neutral): “Although new heritable retrotransposition events take place in the germ line, retrotransposition also occurs in somatic tissues and has been implicated in processes ranging from cancer to brain developmen”
Somatic retrotransposition alters the genetic landscape of the human brain (2011, methodology): “Several lines of evidence support this model, including L1 transcription 8-9 and CNV in brain tissues from human donors of various ages 10-11 as well as mobilization of engineered L1s in vitro and in transgenic rodents 10,12 .”
Neuronal activity modifies DNA methylation landscape in the adult brain (2011, background): “Given the possibility of reactivation of DNA methylation–silenced retrotransposons in intergenic region”
The rise of regulatory RNA (2014, background): “…is evidence that plasticity has been superimposed on RNA-directed epigenetic networks by the expansion of RNA editing, especially during cognitive evolution 296,297 , and by retrotransposon utilization and mobility 114,298–301 , which harks back to the insights of McClintock and Britten & Davidson.”
Nuclear Receptor-Induced Chromosomal Proximity and DNA Breaks Underlie Specific Translocations in Cancer (2009, neutral): “1079 by irradiation (Farkash et al., 2006; Santourlidis et al., 1999), and also with the documented role of PIWIs in silencing LINE-1 repeat movement during neurogenesis ( Muotri et al., 2005 ).”