Targeting macrophages: therapeutic approaches in cancer

By Luca Cassetta, J. Pollard. Nature reviews. Drug discovery, 2018

1,722 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets (2019, background): “Targeting strategies include inhibiting monocyte recruitment, depletion of TAMs, and functional/phenotypic reprogramming (Cassetta and Pollard, 2018).”
Inflammation and Cancer: Triggers, Mechanisms and Consequences (2019, background): “Myeloid cells also present with high degree of plasticity regulated by tumor microenvironment (Cassetta and Pollard, 2018; Yang et al., 2018; Zilionis et al., 2019).”
Regulatory mechanisms of PD-1/PD-L1 in cancers (2024, background): “TAM not only secretes basic vascular endothelial growth factor A, fibroblast growth factor and adrenomedullin to stimulate angiogenesis but also degrades the extracellular matrix, providing nutrition to tumor cells and supporting distant metastasis of tumors [105].”