A call for transparent reporting to optimize the predictive value of preclinical research

By Story C. Landis, S. Amara, K. Asadullah, Chris P. Austin, R. Blumenstein, Eileen W. Bradley, R. Crystal, R. Darnell, R. Ferrante, H. Fillit and 26 more. Nature, 2012

1,158 citations recorded by the source corpus.

The US National Institute of Neurological Disorders and Stroke convened major stakeholders in June 2012 to discuss how to improve the methodological reporting of animal studies in grant applications and publications. The main workshop recommendation is that at a minimum studies should report on sample-size estimation, whether and how animals were randomized, whether investigators were blind to the treatment, and the handling of data. We recognize that achieving a meaningful improvement in the quality of reporting will require a concerted effort by investigators, reviewers, funding agencies and journal editors. Requiring better reporting of animal studies will raise awareness of the importance of rigorous study design to accelerate scientific progress.

Subfields: Public Health, Environmental and Occupational Health, Small Animals, Statistics and Probability

View Paper: https://www.semanticscholar.org/paper/9285f6cc9ff5fafd08e726fe86367641e0ef8ceb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Public Health, Environmental and Occupational Health

In Small Animals

In Statistics and Probability

Citations in the corpus

Reporting animal research: Explanation and Elaboration for the ARRIVE guidelines 2019 (2019, background): “In a hypothesis-testing study powered to detect an effect on the primary outcome measure, data on secondary outcomes are used to evaluate additional effects of the intervention but subsequent statistical analysis of secondary outcome measures may be underpowered, making results and interpretation le”
Reproducibility in Science: Improving the Standard for Basic and Preclinical Research (2015, positive): “They have proposed the inclusion of specific experimental details in addition to more general elements of study design, such as experimenter blinding, randomization of animals, cohorts of sufficient size, inclusion of controls.(18,81) The Global Biological Sciences Institute aims to establish a set ”
Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0 (2020, background): “In a hypothesis-testing study powered to detect an effect on the primary outcome measure, data on secondary outcomes are used to evaluate additional effects of the intervention, but subsequent statistical analysis of secondary outcome measures may be underpowered, making results and interpretation l”
How to Make More Published Research True (2014, background): “There is increasing interest in proposing checklists for the conduct of studies to be approved [46,47], making it vital to ensure both that checklist items are indeed essential and that claims of adherence to them are verifiable.”
Structure and dynamics of molecular networks: A novel paradigm of drug discovery: A comprehensive review (2012, background): “Currently we often lack these high-quality datasets especially on system dynamics (Henney & Superti-Furga, 2008; Prinz et al., 2011; Begley & Ellis, 2012; Landis et al., 2012).”
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research* (2020, positive): “In a hypothesis-testing study powered to detect an effect on the primary outcome measure, data on secondary outcomes are used to evaluate additional effects of the intervention, but subsequent statistical analysis of secondary outcome measures may be underpowered, making results and interpretation l”
An open investigation of the reproducibility of cancer biology research (2014, neutral): “…and funding agencies to improve research practices and to adjust the training and incentives that maintain them ( Ioannidis and Khoury, 2011 ; Landis et al., 2012 ; Miguel et al., 2014 ; Nosek et al., 2012 ; Wagenmakers et al., 2012 ; Wadmann, 2013 ; Alberts et al., 2014 ; Asendorpf et al.,…”