Adipokines and Insulin Resistance
By K. Rabe, M. Lehrke, K. Parhofer, U. Broedl. Molecular Medicine, 2008
868 citations recorded by the source corpus.
Obesity is associated with an array of health problems in adult and pediatric populations. Understanding the pathogenesis of obesity and its metabolic sequelae has advanced rapidly over the past decades. Adipose tissue represents an active endocrine organ that, in addition to regulating fat mass and nutrient homeostasis, releases a large number of bioactive mediators (adipokines) that signal to organs of metabolic importance including brain, liver, skeletal muscle, and the immune system— thereby modulating hemostasis, blood pressure, lipid and glucose metabolism, inflammation, and atherosclerosis. In the present review, we summarize current data on the effect of the adipose tissue-derived hormones adiponectin, chemerin, leptin, omentin, resistin, retinol binding protein 4, tumor necrosis factor-α and interleukin-6, vaspin, and visfatin on insulin resistance.
Subfields: Endocrine and Autonomic Systems, Epidemiology, Physiology
View Paper: https://www.semanticscholar.org/paper/71b39b28c11d5b3178337cc11bf8de1ace869d39
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Citations in the corpus
- Effects of Exercise Training on Cardiorespiratory Fitness and Biomarkers of Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (2015, background): “Obesity has become widely regarded as a chronic proinflammatory state, and substantial evidence indicates that chronic inflammation in adipose tissues, especially in white adipose tissue, could lead to insulin resistance.(211,212) Consequently, it is biologically plausible that by reducing the white”
- Trends in insulin resistance: insights into mechanisms and therapeutic strategy (2022, background): “Dysregulation of these adipokines has been implicated in the onset of obesity, IR, type 2 diabetes, cardiovascular disease, hypertension and metabolic syndromes.(137) Adiponectin is the most abundant protein secreted by adipose tissue and exhibits potent anti-inflammatory properties.”